Digital technologies change our professional and private lives fundamentally. They are the fabric of entrepreneurship and innovation across industries and nations, disrupting existing businesses, and creating new ones. In her inaugural lecture, Prof. Dr. Katharina Hölzle examines the role of digital technologies from three different perspectives - first, as drivers for entrepreneurial operations and the disruptions they cause (digital entrepreneurship), second, as transformers of organizations and business models (digital transformation), and third, for the redesign of innovation policies and innovation systems to account for the consequences of digitalization (digital ecosystems). She will provide an outlook on the changing role of (higher) education for developing a digital mindset.